U-77891 is an opioid analgesic drug that was first synthesized in 1983 by the Upjohn company. It was originally synthesized to prove that the removal of a single methylene spacer of the benzamide would alter a κ-opioid receptor agonist such as U-50488 into an μ-opioid receptor agonist, as well as producing a semi-rigid derivative of U-47700. This would help elucidate the relative positions of the hydrogen-bond acceptors and substituted aromatic system to find the compound with the lowest Ki value in a series of benzamide opioids dating back to the 1970s. The original work found a mixture of agonists and antagonists.
"}{"slip": { "id": 54, "advice": "The more ideas that you give away, the more ideas that will come to you."}}
{"type":"standard","title":"Shy Boy (EP)","displaytitle":"Shy Boy (EP)","namespace":{"id":0,"text":""},"wikibase_item":"Q3959885","titles":{"canonical":"Shy_Boy_(EP)","normalized":"Shy Boy (EP)","display":"Shy Boy (EP)"},"pageid":33787080,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/en/d/d4/ShyBoyJapS.jpg","width":317,"height":314},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/en/d/d4/ShyBoyJapS.jpg","width":317,"height":314},"lang":"en","dir":"ltr","revision":"1164440046","tid":"c0f6fa63-1e28-11ee-8770-5ecb8473f5ff","timestamp":"2023-07-09T07:18:08Z","description":"2011 EP by Secret","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Shy_Boy_(EP)","revisions":"https://en.wikipedia.org/wiki/Shy_Boy_(EP)?action=history","edit":"https://en.wikipedia.org/wiki/Shy_Boy_(EP)?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Shy_Boy_(EP)"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Shy_Boy_(EP)","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Shy_Boy_(EP)","edit":"https://en.m.wikipedia.org/wiki/Shy_Boy_(EP)?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Shy_Boy_(EP)"}},"extract":"Shy Boy is the third extended play by South Korean girl group Secret. The EP was released on November 16, 2011, it contains six songs. All songs are remakes of Secret's Korean songs including \"Shy Boy\" and \"Starlight Moonlight\".","extract_html":"
Shy Boy is the third extended play by South Korean girl group Secret. The EP was released on November 16, 2011, it contains six songs. All songs are remakes of Secret's Korean songs including \"Shy Boy\" and \"Starlight Moonlight\".
"}{"type":"standard","title":"Moșilor","displaytitle":"Moșilor","namespace":{"id":0,"text":""},"wikibase_item":"Q4687494","titles":{"canonical":"Moșilor","normalized":"Moșilor","display":"Moșilor"},"pageid":21857296,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/67/Calea_Mo%C8%99ilor%2C_Bucure%C8%99ti.jpg/330px-Calea_Mo%C8%99ilor%2C_Bucure%C8%99ti.jpg","width":320,"height":180},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/6/67/Calea_Mo%C8%99ilor%2C_Bucure%C8%99ti.jpg","width":1403,"height":789},"lang":"en","dir":"ltr","revision":"1246881965","tid":"b8c28958-7839-11ef-9b7c-fbe048ba46e0","timestamp":"2024-09-21T16:51:18Z","description":"Neighborhood in Bucharest, Romania","description_source":"local","coordinates":{"lat":44.442666,"lon":26.118643},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Mo%C8%99ilor","revisions":"https://en.wikipedia.org/wiki/Mo%C8%99ilor?action=history","edit":"https://en.wikipedia.org/wiki/Mo%C8%99ilor?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Mo%C8%99ilor"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Mo%C8%99ilor","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Mo%C8%99ilor","edit":"https://en.m.wikipedia.org/wiki/Mo%C8%99ilor?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Mo%C8%99ilor"}},"extract":"Moșilor is a residential quarter in Bucharest's Sector 2. It houses the Foișorul de Foc, St. Sylvester's Church, and Olari Church. Its name derives from the main avenue Calea Moșilor which in turn is named after a well-known fair held in Obor square from the 18th century up to the 1950s. The Moșilor quarter is serviced by tram lines 14, 16, and 21, and the M1 Line through Obor metro station.","extract_html":"
Moșilor is a residential quarter in Bucharest's Sector 2. It houses the Foișorul de Foc, St. Sylvester's Church, and Olari Church. Its name derives from the main avenue Calea Moșilor which in turn is named after a well-known fair held in Obor square from the 18th century up to the 1950s. The Moșilor quarter is serviced by tram lines 14, 16, and 21, and the M1 Line through Obor metro station.
"}{"fact":"The heaviest cat on record is Himmy, a Tabby from Queensland, Australia. He weighed nearly 47 pounds (21 kg). He died at the age of 10.","length":135}
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